Tablets in a production line
Crystalline white powder in a measuring spoon spilling out onto a surface
Pill tablets spilling out of a bottle onto a paper with molecular information on it
Production line filling bottles with medication

Powerful Hyperspectral Insights for Precision, Safety and Innovation

Hyperspectral imaging technology is a transformative tool in the pharmaceutical and medical industries by providing non-destructive, real-time physical and chemical analysis at an exceptional level of accuracy and detail.

HSI technology is utilized in pharmaceutical production for continuous monitoring and real-time process control to ensure high-quality end products and regulatory compliance, saving time and preventing wastage. It is useful in the evaluation of different product types including powders, granules, capsules, tablets, emulsions, and liquids. 

By capturing detailed spectral information at every pixel, HSI enables rapid detection of chemical composition, material uniformity, and anomalies that are undetectable by other traditional imaging methods.

Specim hyperspectral camera imaging rows of pharmaceutical tablets

Key Benefits of Hyperspectral Imaging for Pharmaceuticals & Medical:

  • Non-invasive & Non-destructive: HSI enables detailed chemical and structural analysis without modifying samples or requiring invasive biopsies.
  • Real-time Quality Control: Gain continuous, inline monitoring of all stages of production, reducing need for off-line testing and detecting issues immediately.
  • Enhanced Product Safety & Compliance: HSI provides comprehensive data on ingredient classification, concentration, and uniformity ensuring compliance and patient safety.
  • Improved Diagnostic Accuracy: HSI reveals physiological and biochemical changes that can go undetected with conventional imaging methods, allowing for earlier and more accurate detection of abnormalities.
  • Increased Efficiency and Cost Savings: HSI streamlines workflows across pharmaceutical production and clinical applications, leading to lower costs, faster throughput and more sustainable operations.
Pharmaceutical tablets in blister packs side by side image of visible and hyperspectral analysis showing differences only detectable with hyperspectral imaging

Pharmaceutical Research and Development

Pharmaceutical research and development demands tools that can deliver rapid, precise and comprehensive data at every stage of the process, from discovery and formulation, to clinical evaluation. Hyperspectral imaging is quickly becoming an essential technology in this process, offering a unique combination of chemical specificity and spatial resolution that cannot be matched by traditional analytical methods.

 

Common Applications:

  • Compound identification
  • Detection of potential contaminants or polymorphic forms
  • Ingredient distribution map development ensuring uniform blending of APIs and excipients
  • Stability test process monitoring
  • Visualization of how product dissolves or releases for optimization of release profiles or exended-delivery formulations
  • Tissue interaction evaluation, biodiversity assessment and treatment response monitoring for clinical research

 

Case Study: HypeReal System - Hyperspectral imaging solution for the pharmaceutical and biotech industry

Application Video: Specim IQ - Measuring fake drugs

Sensor above moving conveyor imaging pharmaceutical capsules in blister packs

Manufacturing Quality Control and Inspection

Pharmaceutical products are often visually very similar, even indistinguishable, but can have very different chemical compositions or proportions of active pharmaceutical ingredients (API).

Hyperspectral imaging technology offers an accurate and non-destructive method to quickly analyze the chemical composition of a drug during the production process, ensuring correct active dosage and uniformity. Monitoring during the manufacturing process can be done in real-time and can cover the entire material stream in-line with close to 100% accuracy. This allows manufacturers to ensure their products are pure, consistent and safe.

 

Common Applications:

  • Coating uniformity detection
  • Content consistency evaluation
  • Counterfeit product detection
  • Differentiation between APIs, excipients, and contaminants in complex formulations
  • Continuous monitoring and control of blending, drying, granulation, and compression processes

 

Case Study: Sea Vision - Next Level of Pharmaceutical Inspections

Case Study: Indatech - High-speed Analysis of Powder and Tablets with Hyperspectral Imaging

Side by side images showing finger occlusion and related blood volume fraction and skin blood saturation using hyperspectral imaging

Medical Science & Clinical Use

Hyperspectral imaging technology is emerging as a powerful diagnostic tool in medical applications due to it's non-invasive, hygienic and rapid evaluation capabilities. 

Non-contact measurements with hyperspectral imaging systems, such as the Specim IQ, can provide critical insights into tissues, fluids, and physiological conditions. Areas such as surgery, dermatology, ophthalmology and oncology are seeing exceptional growth in the adoption and utilization of hyperspectral imaging technology to deliver faster and improved patient care.

 

Common Applications:

  • Non-invasive spectral analysis of skin, wounds, or surgical margins
  • Detection and evaluation of skin cancers
  • Evaluation of blood circulation and oxygenation efficiency and diabetes-induced blood circulation complications
  • Real-time visualization of tissue types during procedures
  • Evaluation of severity and healing stages of wounds and burns

 

Case Study: CytoViva - HSI Microscopy for Observation and Mapping of Nanoparticles

Application Video: Specim IQ - Health sector goes mobile